Virologists at Temple University Lewis Katz School of Medicine and the University of Nebraska Medical Center have reported successful removal of traces of HIV infection from the DNA of infected mice. The research results were published in the journal Nature Communications.
The study was conducted on the so-called humanized mice, bred specifically for this - they produce human T-lymphocytes, susceptible to HIV infection. Three treatment options have been studied: long-acting antiretroviral therapy (LASER ART), genome editing to remove embedded viral genetic material from mice (CRISPR-Cas9), and a combination of these methods.
As a result, the combination of the two methods made it possible to eliminate HIV from the genetic material of mice. So far, we are not talking about the real possibility of saving people from HIV infection, but only about confirming the concept that it is possible to eliminate it from DNA. Researchers have begun a similar experiment in primates, the preliminary results of which can be expected this year, and the final results no earlier than a year later.
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