Athletes are actively discussing the effect of Nandrolone and Stanozolol on the ligamentous-articular apparatus. Find out how Nandrolone heals, and Stanozolol dries the joint capsules. When it comes to the effect of Nandrolone and Stanozolol on joints in bodybuilding, the ability of the first steroid to retain water is most often mentioned. It is this fact, in the opinion of many athletes, that determines the positive effect of the soundboard on the ligamentous-articular apparatus. Stanozolol, in turn, has the opposite effect and drains the joints. All athletes are familiar with joint pain when using Winstrol. Let's take a closer look at the mechanisms of these steroids and find out the reasons for their effect on the joints.
Mechanisms of work of Nandrolone and Stanozolol
Many athletes know that Stanozolol is produced on the basis of dihydrotestosterone. A fairly large number of athletes experience joint pain when using this anabolic. At the same time, Nandrolone is a 19-nor steroid and has progestogenic properties. At the same time, Deca is very weakly susceptible to aromatization.
Since Nandrolone cannot fully aromatize and become estrogen, there may be a link between the progestogen receptor stimulating effect and the weak estrogenic effect. It is safe to say that during menopause, a decrease in estrogen concentration can lead to a decrease in bone mineral density. When the concentration of female hormones is restored, bone tissue is quickly restored.
Also, scientists have found that progesterone is of great help to estrogens in this. Both of these hormones have a positive effect on collagen as well. If we return to the negative effects of Stanozolol on the joints, then the reason for this should be hidden in the original substance, namely in dihydrotestosterone.
This hormone has the ability to inhibit the effects of female hormones on tissues. In this case, two mechanisms of this effect can be used at once. There is also scientifically proven evidence of the ability of dihydrotestosterone to inhibit the aromatization reaction. This is a rather complex mechanism, but it can effectively reduce the concentration of estrogen. And the last ability of this substance, which should be paid attention to, is the effect of dihydrotestosterone on reducing the rate of synthesis of hormones of the gonadotropic group. In addition to all of the above, dihydrotestosterone reduces the production of progesterone. For these reasons, the hormone effectively eliminates the signs of gynecomastia. Now, to understand the whole issue of the influence of Nandrolone and Stanozolol on joints in bodybuilding, one should mention the special cells TH1 and TH2.
The former accelerate the synthesis of anti-inflammatory cytokines, while the latter activate the process of antibody production. Progesterone and similar sex hormones accelerate the production of TH2 cells and slow down TH1 synthesis. Thus, inflammatory processes are reduced in the body.
Thus, we can say that sex hormones, suppressing immunity at the cellular level (TH1 cells), activate humoral immunity (TH2 cells) and thus have an anti-inflammatory effect on the body. Now let's remember the progestogenic properties of Nandrolone and understand the reason for the decrease in pain when using it.
For the ligamentous-articular apparatus, the positive effect of the use of Nandrolone lies not in the ability of the steroid to retain fluid, but in its anti-inflammatory properties. It is also necessary to recall the scientifically proven property of Nandrolone to affect corticosteroids.
Estrogens in small quantities are able to stimulate cellular immunity and, as a result, inflammatory processes. When the concentration of female hormones increases, their effect is reversed and they suppress TH1 cells (cellular immunity). If you use large amounts of aromatase inhibitors on the cycle, you will drastically reduce the concentration of estrogen, which will lead to pain in the joints. A very good example of this is Letrozole, which can cause joint pain. This drug helps to reduce not only the level of estrogen, but also progesterone.
You can often hear that Letrozole promotes the excretion of fluid from the articular-ligamentous apparatus, which causes pain. Now you know the real reason for this. The pain is caused by a low concentration of female sex hormones.
There is now evidence that testosterone also has anti-inflammatory effects through two mechanisms: conversion to estrogens and effects on corticosteroids.
And in conclusion, we can again return to Stanozolol. Now we already know that joint pain is caused by a decrease in the level of female hormones, and after all, dihydrotestosterone has an inhibitory effect on estrogens. For this reason, the production of TH2 cells is reduced and this causes pain.
For more information on the effect of Nandrolone and Stanozolol on joints, see here:
