Today's article will examine the effects of Deca and Winstrol on joints and ligaments. This is a very relevant question for athletes due to intense physical exertion. The content of the article:
- Effects on joints
- Dihydrotestosterone
- Estrogens
One of the most frequently asked questions on specialized resources is: Nandrolone Decanoate (Deca), Winstrol and your joints, or, in other words, what effect these drugs have on the ligaments and joints. Winstrol is made in the same way as Masteron, from DHT, and many athletes complain of joint problems. At the same time, when using the Deca, the painful sensations disappear, which may indicate a positive effect of the drug on the joints and ligaments.
Effects of drugs on joints
Deca is derived from 19-nor, which is a progestin. From this, we can conclude that Deca is capable of stimulating progesterone receptors, affecting about 20% of the total number of receptors of this type. The drug has a weaker aromatization ability in comparison with testosterone.
Science has clearly established that decreasing estrogen levels during menopause can affect bone mineral density. After replacing estrogens, this density is restored within a short period of time. There is definitely a great merit of progesterone in this, but nevertheless, it is estrogens that play the main role.
Collagen is also improved with an increase in estrogen and progesterone levels. So the question arises: Nandrolone Decanoate (Deca), Winstrol and your joints. What effect does each of the steroids have and why?
The answer is probably hidden in dihydrotestosterone. In the course of clinical studies, it was found that this hormone is able to reduce the level of estrogen, due to the special mechanisms of action on the body. It interferes with estrogens from affecting tissues by acting as an antimetabolite for estrogen receptors or by lowering their coupling. Be that as it may, but there are two types of mechanisms of influence in peripheral areas.
DHT, with its metabolites, is able to resist amortization, which may be the mechanism by which the hormone is able to lower estrogen levels. By and large, dihydrotestosterone, 5alpha-androstenedione, and androsterone are potent inhibitors that interfere with the synthesis of estrone from androstenedione.
And the last established fact speaks of the effect of dihydrotestosterone on the functioning of the endocrine glands, which reduce the rate of synthesis of hormones of the gonadotropic group. It significantly slows down their production.
It should be noted that dihydrotestosterone is very effective in the treatment of gynecomastia and is used as part of a transdermal gel. Everyone knows that gynecomastia is caused by high levels of estrogen, however, progesterone is also implicated in the development of this disease.
Effects of DHT
Dihydrotestosterone is able to suppress the synthesis of progesterone and slow down its synthesis even under the influence of estrogens. It is for this reason that dihydrotestosterone is a very effective means of combating gynecomastia, due to the decrease in progesterone and estrogen levels.
This feature is inherent in all hormone-derived steroids. In studies, it was found that tumors in the breast tissue were reduced under the influence of Masteron. But this is exactly what gynecomastia is. Thus, the first conclusion can be drawn - dihydrotestosterone is able to lower the content of estrogen and progesterone in the body.
Special TH1 cells are called upon to resist inflammatory processes, producing an anti-inflammatory substance cytokine, and TH2 produce antibodies. Progesterone, in turn, accelerates the synthesis of the second type of helper cells and slows down the production of the first. Thus, with an increase in the level of progesterone in the body, more TH2 and less TH1 are produced.
Pregnant women with arthritis can be cited as evidence of the negative effects of progesterone on joints. They note a decrease in joint pain during pregnancy. This is eloquent evidence of the anti-inflammatory effect of progesterone and estrogen on the body.
Since Deca is a progestin-only drug, the steroid is able to stimulate the synthesis of anti-inflammatory helper cells, which explains the analgesic effect on the joints. Thus, the prevailing opinion among athletes that deca relieves chronic joint pain due to fluid retention in the body is refuted. It's all about hormones, not water.
The mechanism of action of estrogens
When the level of estrogen is high enough, the hormone stimulates the synthesis of anti-inflammatory cells, and when its content decreases, the effect becomes the opposite. Therefore, when a large amount of antiestrogens (aromatase inhibitors) is consumed, inflammation can begin in the joints.
By lowering the level of estrogen, the ability to retain fluid also decreases, but more importantly, the decrease in the synthesis of estrogen-progestogen anti-inflammatory reactions with intense training.
Fluid is lost - painful sensations appear in the joints. This was the reason for the emergence of the myth about the effect of excess fluid on the ligaments and joints. The loss of the body's ability to synthesize anti-inflammatory helper cells leads to the appearance of pain.
Watch a video about the effects of Deca on joints:
Based on all of the above, it can be argued that testosterone is also able to fight inflammatory processes due to the properties of aromatization and the ability to affect corticosteroids.
