Antiestrogens are essential in combating high concentrations of female hormones during and after AAC cycles. Find out how to restore the hormonal system after a course? Today, every "chemical" athlete can use antiestrogens during their steroid cycles. However, this was not always the case. About a decade ago, anti-estrogens were expensive enough that not every athlete could use them. Today, a large number of companies have appeared that purchase raw materials for the production of these medicines at very low prices. This led to a sharp drop in prices and the final product. Today you can see the pro's take on the most common anti-estrogens in bodybuilding.
Anti-estrogen drug Tamoxifen Citrate
Tamoxifen is a medication with mixed properties of estrogen receptor agonist and antagonist. He can interact with them and thereby block the effect of female hormones on the body. It should be remembered that the estrogens themselves remain active and are in a free state.
It is widely believed among athletes that Tamoxifen inhibits muscle gain due to its ability to decrease insulin-like growth factor production. At the same time, athletes do not take into account the fact that anabolic steroids will significantly accelerate the synthesis of this hormone and Tamoxifen cannot have a powerful inhibitory effect on this process. It should be said that the drug is very effective as a means of controlling a large number of estrogenic side effects. The average daily dose of the drug is 20 milligrams.
Antiestrogen Clomiphene Citrate
The structure of the Clomid molecule has many similarities with Tamoxifen. This drug is often referred to as a selective estrogen receptor modulator. For the receptor to be activated, the presence of hormone molecules is required, as well as the activation of its two parts - AF-1 and AF-1. Clomid blocks exactly the second factor activating the receptor.
When talking about Clomid, it is necessary to remember its ability to increase the synthesis of the natural male hormone. This is due to the fact that the drug blocks estrogens in the hypothalamus and pituitary gland. Clomiphene has a very reasonable cost and at the same time, unlike a large number of similar drugs, does not violate the lipid balance of the blood. The average daily dose of the drug is in the range from 50 to 100 milligrams.
Anastrozole is the most common antiestrogen
It is a drug from the group of aromatase inhibitors. Anastrozole is able to block the reaction of converting aromatized AAS into female hormones. If we talk about the mechanism of work of the drug, then it is completely different from those described above. If Clomid and Tamoxifen have the ability to block estrogen-type receptors in some tissues and simultaneously activate them in others, then Anastrozole produces such a powerful effect that even high doses of steroids cannot lead to the development of estrogenic side effects.
Relatively recently, this drug was very expensive, and this sharply limited the possibility of its use in bodybuilding. For example, back in 2001, 28 tablets of the drug cost about $ 300. Now a similar package is priced at about $ 40. This sharp drop in the price of the drug has allowed a large number of athletes to start using it in their anabolic cycles. It also became possible to increase the dose of steroids without fear of possible side effects. If we compare the effectiveness of Tamoxifen, Clomid and Anastrozole, then the latter is in the lead by a huge margin from its competitors.
Exemestane is a steroidal antiestrogen
All drugs of the aromatase inhibitor group are usually divided into two types - type 1 and type 2. The first group includes drugs with a steroidal structure of molecules, say, Exemestane. In turn, the second is made up of non-steroidal medications, say, Anastrozole or Letrozole.
The effectiveness of Exemestane exceeds that of Anastrozole by about fifty percent. Using the same dosage of these inhibitors, Exemestane will increase the production of the male hormone by 60 percent and decrease the globulin concentration by another 20. This will further increase your testosterone levels. Thus, Exemestane is an excellent tool for carrying out rehabilitation therapy after a cycle of anabolic steroids. The average daily dose of the medication is from 10 to 1.2 milligrams.
Letrozole is a non-steroidal antiestrogen
Today Letrozole is the most potent drug in the group of aromatase inhibitors. Due to its greater effectiveness in comparison with Exemestane and Anastrozole, it is very widely used by athletes. Thanks to Letrozole, you can not only prevent the development of side effects, but also eliminate those that have already appeared.
The only drawback of the drug can be considered its ability to dry the joints. This is due to the fact that female hormones are very important for the health of the ligamentous-articular apparatus and the performance of the immune system. When you start to feel pain in your joints, you should begin to reduce the dose of Letrozole until they are completely eliminated.
For more information on the effect of anti-estrogen drugs on the body, see this video:
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